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IVF with PGD #104


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#51 Gee gee

Posted 31 December 2013 - 05:32 AM

Mrs Bee, with my AMH ( which is quite high for my age) both me and my FS were expecting more eggs. But I was on quite a low dose of drugs which goes some way to explaining the poor response.

Only one embryo made it to day 5 which we chose to transfer rather than have it tested. I have just found out this cycle wasn't successful.

I think I probably only have one more full cycle in me before I think we will stop actively ttc. My FS has said she would double the drugs on another cycle and hopefully we will get more eggs. With PGD, it's just such a numbers game and as so few embryos make it to day 5 you really want a lot to start with. Even though we only have about a 5% chance of any child being affected by DH's chromosome abnormality I would still prefer to do PGD as I have had a miscarriage and chemical pregnancy before and would like to avoid both again, if possible.

Our cycle started a few days after we signed consent forms, ie it moved very quickly.

Good luck with the start of your IVF journey and I will post again when cycle 2 starts for us.

Edited by Gee gee, 31 December 2013 - 05:33 AM.


#52 Mrs.Bee

Posted 31 December 2013 - 09:01 AM

I'm sorry to hear that this cycle was unsuccessful and that only 1 egg made it to day 5.
I too have a high AMH so I anticipate to be commenced on a lower dose, I guess to try and avoid OHSS.
I will keep you in my thought as you head towards the next cycle.
Mrs.Bee x

#53 Peta Feral

Posted 06 January 2014 - 05:58 PM

Good luck Mrs Bee and Gee Gee. I havent been here much since my 5th cycle last December came back with no embryos making it to testing on day 5 - its all getting a bit dispiriting. But I have been around the block with IVF with PGD so feel free to ask me anything :)

#54 Gee gee

Posted 09 January 2014 - 07:19 PM

Sorry to hear that PetaSiddle, that really sucks :( Have you ever thought of just trying your luck with straight IVF? That is something I am starting to weigh up.

We're having this cycle off and into another stim cycle next month. I really hope that with a few changes to the procedure, we will have a better response ext time.

Edited by Gee gee, 09 January 2014 - 07:19 PM.


#55 Peta Feral

Posted 17 January 2014 - 03:15 PM

Hi Gee Gee, do you mean with no PGD? Our odds of a viable embryo are 1/6, so if we were going to do IVF without PGD we really might as well just keep trying naturally. I have no trouble getting pregnant - before we started on IVF with PGD I had five early miscarriages.

#56 fxd

Posted 28 January 2014 - 09:46 PM

Hi Ladies,  I'm new to PDG (well I've tried before but never made it to testing) and am about to start my cycle. I've got a whole story which I'll share in a little while when I have some more time, but for now, just a quick question that I was hoping someone could answer.  I'm on day 1 tomorrow and usually I start injections (FSH I think) on day 2 (it has always seemed critical that I do this timing.  Suddenly the nurses are telling me that because I'm doing PDG I'm not to start injections until Saturday  (day 4).  I think it has something to do with the scientists not wanting to work weekends??  Anyway, I'm starting to freak out a little as so much is resting on this cycle and I hate the thought of doing anything that could hamper it, like start FSH when my follies have already started developing.  My body isn't clockwork and generally I go to harvest later than most (would they want to change this too??) so my follies are large enough. I've done this quite a few times now so am so used to the regular timing that has always been stressed as crucial.   I can't see anything in the fertilisation, embryo development side is different.  i may just be paranoid.... anyone know anything about this?  Help!!

By the way thanks in advance :smile:

#57 Sparky10

Posted 29 January 2014 - 04:51 PM

Hi fxd

What type of cycle are you doing? I'm doing antagonist cycles and I started injecting on day 4 last cycle due to some issues with my hormone levels (I have previously started on day 2 as well). The nurses assured me that it would be ok. It wasn't my best cycle in terms of eggs numbers but this could be unrelated. I think it is worth querying why they are starting you so late. At my clinic the scientists work everyday but I do know others schedule peoples cycles around their staff.

#58 trinity168

Posted 19 February 2014 - 08:03 PM

hi,

back on the forum since 2010. Been a long journey of TTC.  Brief history, TTC since 2010, had 2 natural pregnancies, and m/c on both occassions.  Felt as though we could do it on our own, so kept at it, seeing a natural fertility specialist, accupunture, kiniesiologist, bio-med.  Drew the line last December since we are still not parents.

DH - 34
Me - close to 40

DH has morphology issues.
Me- amh @ 9. MTHFR with a dodgy gene.


On 2nd m/c, found little sticky had trisonomy 14.

Now here we are, on day 8 doing ICSI/PGD.  Scheduled egg collection on Saturday. On antagonist cycle.

CD8 results
Estrogen= over 4000
Progesterone = 4.8
L.H. = 4.2
Endrimitrium = 11

Right ovary = 2 follicles @ 19 & 19
Left ovary = too small to see, sonographer reckons there is "gas".

I thought I was afraid of the needles but realized, it's the emotional aspect that is really difficult.

Thought I'd come back to the forum to be with people who are going through the same journey.  And, hopefully, we all get our hearts desire and what we have been praying for.


Cheers,
trinity168

#59 trinity168

Posted 22 February 2014 - 08:39 PM

Just an update, only found one egg and scientist rang to say that the egg was immature.  :(

Had ovidrel trigger Thursday evening.  Egg collection this Saturday morning.

Side effects. After the trigger, started to feel sore muscles, especially lower back and left side.  Had acupuncture Friday evening.  Woke up Saturday morning with much reduced muscle soreness.

After egg collection, extremely drowsy.  Took panadene before local anesthetic wears off.  Slept for hours.

:cry:

#60 Gee gee

Posted 03 March 2014 - 06:03 PM

Trinity, I'm sorry to read it didn't work for you this cycle.

AFM, we had a failed cycle in December (only 1 emby so no PGD testing). Next cycle, we fell pregnant naturally but have just had a miscarriage at 8 weeks. When my AF returns we intend to do another cycle with the aim of PGD testing again. I just hope we get a couple of embies to test....


#61 trinity168

Posted 04 March 2014 - 08:10 PM

hi GeeGee,

We start our next cycle tomorrow. FS didn't want us to have a break in between but wanted to ride on the "momentum" of the drugs from previous cycle.

Do the forum members mind posting what they are on? E.g. dosage of gonal-F ... Or is that prohibited?


Thanks.

#62 Gee gee

Posted 04 March 2014 - 08:35 PM

Trinity,

That's great that you can do back to back cycles.

I was on Gonal F 180 (and something else but I have forgotten). It was a conservative approach because I have a relatively high AMH. But I didn't respond well and had 6 eggs, all fertilized with ICSI but only 1 made it to a 5 day blast.

Next time I think I will be on at least 300 Gonal F to try and get more eggs/embies for testing. I really hope we have a better response this time. If not, I don't think IVF will be able to help us.

#63 trinity168

Posted 04 March 2014 - 08:50 PM

Hi GeeGee,

Yeah, couldn't be disappointed or anything like that, had to move on quickly.

I was on gonal-F 300 on my first cycle.  I will be on 375 on the next cycle.

AMH @ 9 last tested in Dec 2013.

Fingers crossed for you on your next cycle.  Don't give up. Miracles around the corner for us ...

#64 Mixed_Spice

Posted 08 March 2014 - 12:12 PM

Hi everyone again. I was here a long time ago (maybe a year). I had to put off my PGD as they wanted me to have surgery. It was such a hard decision, but I am glad I did it now as we had time to check out the assistance program and then we got accepted!! We only have this year though, so if we encounter any issues then it will be out of our pocket. We have met with our FS and have done our blood tests, pelvic examination and we are going to Sydney next week to do the sperm test and meet all the people. How long did it take everyone else from this point?

#65 Gee gee

Posted 09 March 2014 - 12:16 PM

Mixed_spice, our first cycle all happened very quickly (ie. after all the tests etc were done, we had a meeting with the FS and started cycling 2 days later).

I am on cd11 and just waiting for AF to arrive to start cycle 2.

#66 Mixed_Spice

Posted 10 March 2014 - 10:32 AM

Oh wow, I can't believe that it could be so soon. I understand everyone is different, but how many needles do you take each day? Are there pills to take as well? And how did everyone react? Did you associate your reaction to how you react to the pill? I.e. If you have bad reactions to the pill did you have bad reactions to the medication?
Sorry for asking so many questions, this is my first time doing anything regarding trying to conceive a child, so I feel a bit short on the info at the moment.

#67 Gee gee

Posted 10 March 2014 - 12:37 PM

Mixed_spice, I have only done one cycle and I'm sure everyone has different medications. But I had one needle a day until egg pick up, and closer to egg pick up they also added in another needle (so 2 needles a day) and then finally the trigger shot. This all went on for 12 days for me.

I found the needles fine and the medication was also OK for me too. I was more tired than usual but nothing I couldn't cope with easily. It was definitely easier on my body than expected, but it was an emotional and stressful experience nonetheless.

Your clinic will go through it with you in a lot of detail. Good luck and keep us posted on how you go.

#68 trinity168

Posted 10 March 2014 - 06:31 PM

Hi Mixed_spice,

I am on round 2 - antagonist cycle.

First 5 days, 1 needle. Then becomes 2 needles after that.

This round, am getting slight headaches.  As gee gee pointed out, it's tiring running around for the tests but the emotional part is challenging.  

I am on a plethora of supplements, with MTHFR issues.  Have had numerous test as well.

No coffee for a year now, was only on weak cappuccino to start with.  Buying organic as much as we can.  No alcohol for 9 months now.  More conscious about gluten and preservatives.


God bless.  And, ask away!

#69 Sallymbo

Posted 13 March 2014 - 10:59 PM

Hi,
I am new hear and currently waiting for PGD results and going insane!!!  We are a "mature" couple (me, 42, DH, 46) desperately hoping to gave a baby brother or sister for our 4 year old (conceived naturally).
We have no known genetic issues but decided on PGD after 3 failed transfers.  1st retrieval got 9 mature eggs but only 3 fertilised and 2 got to Day 3.  8 cell day 3 transferred BFN and then very good day 5 transferred...same story.
2nd retrieval again 9 mature, 7 fertilised.  We discovered I had some adenymiosis so transferred the lowest quality (4 cell) and froze remaining 6 as we decided to do the PGD while getting treatment for the condition.  BFN as expected.
So got permission from RTC to do one more retrieval cycle to increase chances of PGD normal.  Again, 9 retrieved but had terrible time with the sedation.  Still, 8 fertilised and at day 3 we unfroze the snow babies and 5 made it.  
Decided to take them to day 5 for biopsy and 4 made it with 1 other that couldn't be biopsies due to very thin trophoderm.
Anyway, excuse my indulgence but this is the first time I have been able to share my story with others who understand the numbers as well as the emotion.
So I am waiting for results from the 4 blasts and going crazy.  I have tried to find information on the chances of PGD normal embryos at day 5 but it seems like it is fairly new and there is not much there so I am hoping to hear from others.
I have another week and a half to go for the results and I am trying to stay as busy as possible but it is still turning me into a madwoman.
Any insight would be so welcome.

#70 Sallymbo

Posted 13 March 2014 - 11:03 PM

Hi,
I am new hear and currently waiting for PGD results and going insane!!!  We are a "mature" couple (me, 42, DH, 46) desperately hoping to gave a baby brother or sister for our 4 year old (conceived naturally).
We have no known genetic issues but decided on PGD after 3 failed transfers.  1st retrieval got 9 mature eggs but only 3 fertilised and 2 got to Day 3.  8 cell day 3 transferred BFN and then very good day 5 transferred...same story.
2nd retrieval again 9 mature, 7 fertilised.  We discovered I had some adenymiosis so transferred the lowest quality (4 cell) and froze remaining 6 as we decided to do the PGD while getting treatment for the condition.  BFN as expected.
So got permission from RTC to do one more retrieval cycle to increase chances of PGD normal.  Again, 9 retrieved but had terrible time with the sedation.  Still, 8 fertilised and at day 3 we unfroze the snow babies and 5 made it.  
Decided to take them to day 5 for biopsy and 4 made it with 1 other that couldn't be biopsies due to very thin trophoderm.
Anyway, excuse my indulgence but this is the first time I have been able to share my story with others who understand the numbers as well as the emotion.
So I am waiting for results from the 4 blasts and going crazy.  I have tried to find information on the chances of PGD normal embryos at day 5 but it seems like it is fairly new and there is not much there so I am hoping to hear from others.
I have another week and a half to go for the results and I am trying to stay as busy as possible but it is still turning me into a madwoman.
Any insight would be so welcome.

#71 trinity168

Posted 17 March 2014 - 05:39 PM

Hi Sallymbo -- can't provide much insight but just wanted to say "hi". I am on an IVF cycle ( round 2 ) and, hoping to do PGD as well.  I think there is not a lot of material that I have read about PGD.  Best of luck to you and your little embie.

#72 Gee gee

Posted 17 March 2014 - 06:38 PM

Welcome Sallymbo.

I have only had one stim cycle so far and we transferred 1 day 5 blast, which we didn't test (BFN). So I can't help you either. I think that outcome of normal embies after PGD can very enormously though, depending on different factors.

I have now ovulated after my miscarriage (ovulated on day 18 instead of day 13, so not too bad). I reckon I will be starting injections in about 2 weeks. I am feeling very positive for cycle 2 for some unknown reason.

Trinity how is your cycle going?

Edited by Gee gee, 17 March 2014 - 06:39 PM.


#73 trinity168

Posted 19 March 2014 - 08:56 PM

hi GeeGee,

Had EPU on Tuesday, got 7 eggs.  Embryologist rang in the arvo and said that #7 had dropped off, looking likely that #6 didn't like ICSI.  So we have 5 beautiful embies from which we hope to bring home a healthy bub. It's a waiting game from this time on.

For this cycle, gonal-F went up to 450 at one point. Then switched to menopur.  Trigger night was ovidrel and lucrin. Symptoms include, dizziness, felt like vomiting after a meal, early on had slight headaches, feel soo tired.

Feeling relived that we got eggs this time around.  Waiting game, depending on how things go, decisions to be made, e.g. a transfer without testing, or wait for PGD.

Off to bed!  Get good rest girls.

Praying for miracles around the corner for us!

8)

#74 Gee gee

Posted 20 March 2014 - 07:19 AM

Great news Trinity. Fingers crossed those 5 embies continue on for transfer or testing.

Still waiting for AF here! Wish it would hurry up so that we can get started. We have an appointment with our FS this Monday. I want to go through our proposed cycle in some detail, as I felt our last cycle was generally a failure all round (although I know they say the first cycle is really a test run).

#75 trinity168

Posted 20 March 2014 - 07:29 PM

Hi GeeGee,

I'd agree that the first cycle is a test run.  I guess a good FS is one that should tweak your injections/meds for the next cycle and tailor fit it for you.  I take notes each time the nurses call, I get my numbers and results. It's just my personality I guess. ( A short pen is better than a long memory ).

How did you feel after EPU?  Am still quite sore and, try and have a heat pack whenever I can.  I had panadeine immediately after the procedure and no more.

Other things we do:  no mobile phones near the bed, wi-fi turned off when we go to bed.  Since we did that, feels like I sleep much better at night.

Good night, sweet dreams.


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